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KMID : 0363320060270040879
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Journal of Korean Oriental Internal Medicine
2006 Volume.27 No. 4 p.879 ~ p.887
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Effects of Jinmutang (JMT) on Hypothyroidism in Rats
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Choi In-Gu
Chae Eun-Young
Chang Sun-Kyu
Cho Chung-Sik
Kim Cheol-Jung
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Abstract
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Objectives : This study was done to investigate the effects of JMT on hypothyroidism in rats.
Materials and Methods : After pretreatment with 50mg/kg thiouracil for 30 days, the experimental group was treated with 0.56g/kg JMT orally and the control group was treated with 0.56g/kg of normal saline instead for 20 days. The various indicators related to hypothyroidism were measured, such as T3-uptake content, T3 content, T4 content, TSH content, hematological values, enzyme activity, total cholesterol content, Na+ content change in the serum and body weight of rats induced by thiouracil.
Results : The JMT-treated group showed significant increase in comparison with the control group in serum T3-uptake and T4 content. The JMT-treated group also showed significant decrease in comparison with the control group in serum TSH content. However, the JMT-treated group did not show significant increase in comparison with the control group in serum T3 content. The JMT-treated group showed significant increase in comparison with the control group in serum RBC. The JMT-treated group showed significant decrease in comparison with the control group in serum CPK, ALP, LDH content and serum total cholesterol content. The JMT-treated group did not show significant increase in comparison with the control group in serum Na+ content. The JMT-treated group showed significant decrease in comparison with the control group in body weight.
Conclusions : These results suggest that JMT is useful in treatment of hypothyroidism.
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KEYWORD
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Jinmutang(JMT), Hypothyroidism
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